[paragraph] 最早的H7N9病毒记录:1988年,来自美国卫生部 (2013-04-23 02:06:41)
在网上查到关于H7N9禽流感最早的记录,来自美国卫生部,美国国家生物技术信息中心;时间:1988年,地点:美国明尼苏达州,感染动物:火鸡。科学杂志2006年某刊作为索引文献的15个作者中,6人姓名看起来是中国人。病毒的基因序列也列在文章中。网址如下:
http://www.ncbi.nlm.nih.gov/nuccore/CY014787.1Influenza A virus(A/turkey/Minnesota/1/1988(H7N9)) segment 7, complete sequence
GenBank: CY014787.1
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LOCUS CY014787 1027 bp cRNA linear VRL 21-SEP-2006
DEFINITION Influenza A virus (A/turkey/Minnesota/1/1988(H7N9)) segment 7,
complete sequence.
ACCESSION CY014787
VERSION CY014787.1 GI:115278574
KEYWORDS .
SOURCE Influenza A virus (A/turkey/Minnesota/1/1988(H7N9))
ORGANISM Influenza A virus (A/turkey/Minnesota/1/1988(H7N9))
Viruses; ssRNA negative-strand viruses; Orthomyxoviridae;
Influenzavirus A.
REFERENCE 1 (bases 1 to 1027)
AUTHORS Obenauer,J.C., Denson,J., Mehta,P.K., Su,X., Mukatira,S.,
Finkelstein,D.B., Xu,X., Wang,J., Ma,J., Fan,Y., Rakestraw,K.M.,
Webster,R.G., Hoffmann,E., Krauss,S., Zheng,J., Zhang,Z. and
Naeve,C.W.
TITLE Large-scale sequence analysis of avian influenza isolates
JOURNAL Science 311 (5767), 1576-1580 (2006)
PUBMED 16439620
REFERENCE 2 (bases 1 to 1027)
AUTHORS Obenauer,J.C., Denson,J., Mehta,P.K., Su,X., Mukatira,S.,
Finkelstein,D.B., Xu,X., Wang,J., Ma,J., Fan,Y., Rakestraw,K.M.,
Webster,R.G., Hoffmann,E., Krauss,S., Zheng,J., Zhang,Z. and
Naeve,C.W.
TITLE Direct Submission
JOURNAL Submitted (13-SEP-2006) Hartwell Center for Bioinformatics &
Biotechnology, St. Jude Children's Research Hospital, 332 North
Lauderdale Str., Memphis, TN 38105, USA
FEATURES Location/Qualifiers
source 1..1027
/organism="Influenza A virus
(A/turkey/Minnesota/1/1988(H7N9))"
/mol_type="viral cRNA"
/strain="A/turkey/Minnesota/1/1988"
/serotype="H7N9"
/host="Avian"
/db_xref="taxon:402490"
/segment="7"
/country="USA: Minnesota"
/collection_date="13-Jul-1988"
primer_bind 1..15
/note="CR amplification primer sequence"
gene 26..1007
/gene="M2"
CDS join(26..51,740..1007)
/gene="M2"
/codon_start=1
/product="matrix protein 2"
/protein_id="ABI84696.1"
/db_xref="GI:115278576"
/translation="MSLLTEVETPTRNGWECKCSDSSDPLVIAASIIGILHLILWILD
RLFFKCIYRRLKYGLKRGPSTEGVPESMREEYRQEQQSAVDVDDGHFVNIELE"
gene 26..784
/gene="M1"
CDS 26..784
/gene="M1"
/codon_start=1
/product="matrix protein 1"
/protein_id="ABI84695.1"
/db_xref="GI:115278575"
/translation="MSLLTEVETYVLSIVPSGPLKAEIAQRLEDVFAGKNTDLEALME
WLKTRPILSPLTKGILGFVFTLTVPSERGLQRRRFVQNALNGNGDPNNMDRAVKLYRK
LKREITFHGAKEVALSYSTGALASCMGLIYNRMGTVTTEVAFGLVCATCEQIADSQHR
SHRQMVTTTNPLIRHENRMVLASTTAKAMEQMAGSSEQAAEAMEVASQARQMVQAMRT
IGTHPSSSAGLKDDLLENLQAYQKRMGVQMQRFK"
primer_bind complement(1007..1027)
/note="CR amplification primer sequence"
ORIGIN
1 agcaaaagca ggtagatatt gaaagatgag tcttctaacc gaggtcgaaa cgtacgttct
61 ctctatcgtc ccgtcaggcc ccctcaaagc cgagatcgcg cagagacttg aagatgtctt
121 tgcagggaag aacaccgatc ttgaggcact catggagtgg ctaaagacaa gaccaatcct
181 gtcacctctg accaagggga ttttaggatt tgtgtttacg ctcaccgtgc ccagtgagcg
241 aggactgcag cgtagacgct ttgtccaaaa tgcccttaat gggaatgggg atccaaacaa
301 catggacaga gcagtcaaac tatacaggaa actaaaaagg gaaataacat tccatggggc
361 aaaagaagta gcactcagtt attcaactgg tgcacttgcc agttgcatgg gcctcatata
421 caacagaatg gggactgtga ccaccgaagt ggcatttggc ctggtgtgcg ccacatgtga
481 gcagattgct gattcccagc atcggtctca cagacaaatg gtgacaacaa ccaacccact
541 aatcagacat gagaacagaa tggtactagc cagtactacg gctaaagcca tggagcaaat
601 ggcaggatca agtgagcaag cagcagaggc tatggaggtt gctagtcagg ctaggcaaat
661 ggtgcaggca atgaggacca ttggaactca tcctagctcc agtgctggtc taaaagatga
721 tcttcttgaa aatttgcagg cctaccagaa acggatggga gtgcaaatgc agcgattcaa
781 gtgatcctct cgttattgcc gcaagtatca ttgggatctt gcacttgata ttgtggattc
841 ttgatcgtct tttcttcaaa tgcatttatc gtcgccttaa atacggtttg aaaagagggc
901 cttctacgga aggagtgcct gagtctatga gggaagaata ccggcaggaa cagcagagtg
961 ctgtggatgt tgacgatggt cattttgtca acatagagct ggagtaaaaa actaccttgt
1021 ttctact
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